The Curriculum
Module 1: Introduction to Medicine
- Medical terminology
- Word structure
- Common prefixes, roots and suffixes
- System based medical terminology – cardiology, pulmonology, gastroenterology, neurology
- Quiz
- Medical ethics
- Four major ethical principles in medicine
- Autonomy
- Justice
- Beneficence
- Non-maleficence
- Institutional review boards (IRBs)
- What is an IRB?
- Function of an IRB
- Ethical review processes
- Definition and Importance of Informed Consent
- Components of Informed Consent
- Ethical Considerations in Informed Consent
- Identifying Vulnerable Populations
- Safeguarding the Rights of Vulnerable Populations
- Violations of Medical Ethics in History
- The Tuskegee Syphilis Study (1932-1972)
- Nazi Medical Experiments (1930s-1945)
- Forced Sterilizations in the United States (20th Century)
- Henrietta Lacks and the HeLa Cells (1950s)
- Quiz
- Four major ethical principles in medicine
- Patient History & Physical Exam
- Components of the patient history
- Example of a patient history
- Review of systems
- Physical exam components
- Diagnostic reasoning
- Steps in differential diagnosis
- Important considerations in differential diagnosis – common conditions, red flags, do not miss diagnoses
- Case study
- Public health
- Primary, secondary and tertiary prevention
- History of vaccines
- Importance of vaccines
- Herd immunity
- Antibiotic resistance
- Antibiotic stewardship
Module 2: Medical Research
- Terminology
- Primary research question and hypotheses
- Independent and dependent variable
- Primary outcome and secondary outcome
- Types of medical research studies
- Case control studies
- Cohort studies
- Randomized control trials
- Epidemiological studies
- Qualitative studies
- Meta analyses
- Historical milestones in medical research
- Analysis of real-world medical research studies
- Study design
- Participant characteristics
- Variables and measurements
- Data collection and analysis
- Statistical and clinical significance
- Discussion and conclusion interpretation
- Critical appraisal of research findings
- Application of knowledge – case studies
- Quiz
Module 3: Genetics
- History of genetics
- Basic concepts & terminology
- Genes
- Alleles
- Chromosomes
- Genotype vs phenotype
- Homozygous vs heterozygous
- Dominant vs recessive alleles
- Genetic crosses
- Mendel’s laws of inheritance
- Mendel’s experiments
- Law of segregation
- Law of independent assortment
- Punnett squares and genetic crosses
- Construction of Punnett squares
- Filling in the Punnett square
- Predicting genotypic and phenotypic ratios
- Examples
- Inheritance patterns
- Autosomal dominant inheritance
- Autosomal recessive inheritance
- X linked inheritance
- Chromosomal basis of inheritance
- Chromosome structure & organization
- DNA composition
- Histone proteins
- Chromatin structure
- Centromeres
- Telomeres
- Karyotype
- Chromosome abnormalities
- Aneuploidy
- Translocations
- Deletions
- Duplications
- Inversions
- Molecular basis of inheritance
- DNA structure & replication
- Double helix
- Base pairing and complementary strands
- Antiparallel orientation
- DNA replication (initiation, elongation, termination)
- Enzymes involved in DNA replication
- Proofreading & repar
- Mismatch repair enzymes
- RNA structure & replication
- RNA transcription, translation & genetic code
- Types of RNA
- Post-transcriptional modifications
- Protein synthesis (translation)
- Protein folding and modification
- Genetic Variation
- Mutations and their types (e.g., point mutations, insertions, deletions)
- Spontaneous mutations
- Induced mutations
- Replication errors and DNA repair defects
- Epigenetics
- Role of epigenetics in gene regulation and disease
- Genetic Disorders
- Autosomal dominant disorders (e.g., Huntington's disease, Marfan syndrome)
- Autosomal recessive disorders (e.g., cystic fibrosis, phenylketonuria)
- X-linked disorders (e.g., hemophilia, Duchenne muscular dystrophy)
- Genetic Testing and Counseling
- Types of genetic tests (e.g., diagnostic, predictive, carrier screening)
- Ethical considerations in genetic testing
- Role of genetic counseling in patient care
- Genetic Engineering and Biotechnology
- Gene editing techniques (e.g., CRISPR-Cas9)
- Applications in medicine, agriculture, and industry
- Â Ethical dilemmas
- DNA structure & replication
- Chromosome structure & organization
- Quiz
Module 4: Immunology
- History of immunology
- Basic concepts & terminology
- Innate immunity
- Physical barriers (e.g., skin, mucous membranes)
- Cellular components (e.g., phagocytes, natural killer cells)
- Chemical mediators (e.g., cytokines, complement system)
- Adaptive immunity
- Antigens
- Antibodies
- Antibody subtypes
- Antibody effector functions (e.g., opsonization, neutralization, complement activation)
- B-cell immunity (humoral immunity)
- T-cell immunity (cellular immunity)
- T-cell subsets (e.g., helper T cells, cytotoxic T cells, regulatory T cells)
- Cytokines and their roles in cell-mediated responses
- Immunological memory
- Vaccination
- Types of vaccines (e.g., live attenuated, inactivated, subunit, conjugate)
- Immunodeficiency Disorders
- Primary immunodeficiencies
- Genetic basis
- Types of primary immunodeficiencies
- Clinical features
- Diagnosis & management
- Acquired immunodeficiencies
- HIV / AIDs
- Transmission & risk factors
- Clinical manifestations
- Diagnosis & management
- Autoimmune disease
- Loss of self-tolerance
- Molecular mimicry
- Release of sequestered self-antigens
- Defective immune regulation
- Epigenetic modifications
- Examples of autoimmune disease
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Hashimoto thyroiditis
- Type 1 diabetes
- Hypersensitivity reactions
- Types I, II, III, and IV hypersensitivity
- HIV / AIDs
- Primary immunodeficiencies
- Quiz
Module 5: Cardiology
 Module 5: Cardiology
- Anatomy & physiology of the heart
- Chambers of the heart
- Blood flow through the heart
- Electrical conduction system of the heart
- Vitals
- Chest painÂ
- Angina
- Myocardial infarction
- Treating acute coronary syndrome
- Primary and secondary prevention of heart attack
- Disorders of the blood vessels
- Hypertension
- Peripheral artery disease
Chronic venous insufficiency
- Arrhythmias
- Atrial fibrillation
- Heart block
- Heart failure
- Left vs right heart failure
- Acute vs chronic heart failure
- Systolic vs diastolic heart failure
- Murmurs
- Aortic stenosis
- Mitral regurgitation
- Congestive heart disease
- Hypertrophic cardiomyopathy
- Quiz
Module 6: Pulmonary
- Anatomy and physiology in the lungs
- Components of the respiratory systemÂ
- Structure of the lungs
- Ventilation vs oxygenation
- Pleura
- Pulmonary circulation
- Lung volumes & capacitiesÂ
- Diseases of the lung
- COPD (bronchitis, emphysema)
- Clubbing
- Asthma
- Atopic triad
- Pulmonary fibrosis
- Sarcoidosis
- Corticosteroids & their effects
- Pneumonia
- Pneumonia vs upper respiratory infection
- Pulmonary embolism
- Pulmonary hypertension
- Pulmonary edemaÂ
- Pleural effusion
- Pneumothorax
- Airway disease
- Lung tissue disease
- Lung circulation disease
- Diseases of the pleura
- Quiz
Module 7: Gastroenterology
- Anatomy and physiology of the GI tract
- Salivary glands, taste buds, receptors in the mouth
- Anatomy and physiology of the esophagus
- Physiology of swallowing
- Anatomy and physiology of the stomach
- Chemical and mechanical digestion
- Anatomy and physiology of the intestines
- Anatomy and physiology of the liver
- Anatomy and physiology of the gallbladder
- Bile & bile acids
- Physiology of the pancreas
- Diagnostics
- Endoscopy
- Colonoscopy
- Sigmoidoscopy
- Lab tests relevant to the GI tract
- Diseases of the GI tract
- Esophageal diseases
- Achalasia
- Barrett’s esophagus
- Eosinophilic esophagitis
- Gastroesophageal reflux disease (GERD)
- Peptic ulcer disease
- Gastrointestinal infections
- Helicobacter pylori
- Clostridium difficile
- Inflammatory bowel disease
- Crohn's disease
- Ulcerative colitis
- Celiac disease
- Irritable bowel syndrome (IBS)
- Liver diseases
- Hepatitis
- Non-alcoholic fatty liver disease (NAFLD)
- Cirrhosis
- Gallbladder diseases
- Cholecystitis
- Pancreatic diseases
- Pancreatitis
- Esophageal diseases
- Quiz
Module 8: Neurology
- Anatomy & physiology
- Divisions of the nervous system
- Gross anatomy of the brain
- Microscopic physiology of the brain
- Cerebrospinal fluid (CSF)
- Blood brain barrier (BBB)
- Diseases of the nervous system
- Stroke
- Ischemic vs hemorrhagic stroke
- Seizure
- Neurodegenerative diseases
- Dementia
- Alzheimer’s disease
- Vascular dementia
- Frontotemporal dementia
- Screening for dementia (MMSE, MOCA)
- Parkinson’s disease
- Multiple sclerosis
- Headache
- Primary vs secondary headache
- Migraine headache
- Tension headache
- Cluster headache
- Red flags in diagnosis of headache Â
- Neuroinfectious
- Meningitis
- Neurosyphilis
- Movement disorders
- Essential tremor
- Restless leg syndrome
- Neuro-oncology
- Glioblastoma multiforme
- Stroke
- Quiz
Module 9: Hematology
- Overview of blood components (erythrocytes, leukocytes, platelets)
- Functions of blood
- Blood type & cross typing
- Introduction to hematopoiesis
- Peripheral blood smear
- Bone marrow structure and function
- Bone marrow aspiration and biopsy
- Reading blood work (complete blood count)
- Disorders of the blood and bone marrow
- Red blood cell disorders
- Anemia
- Lab tests in anemia
- Causes of anemia
- Polycythemia vera
- Thalassemia
- Sickle cell disease
- Reticulocytes – Splenic sequestration & Aplastic crisis
- White blood cell disorders
- Leukocytosis
- Leukemia
- Lymphoma
- Platelet disorders
- Thrombocytopenia
- Thrombocytosis
- Coagulation disorders
- Hemophilia
- DIC
- Interactive cases
- Quiz
Module 10: Dermatology
- Overview of the structure and function of the skin
- Skin cells
- Skin examination
- Lesion morphology and terminology
- Dermatologic procedures
- Biopsy
- Cryotherapy
- Excisional surgery
- Disease of the skin
- Acne vulgaris
- Isotretinoin (Accutane)
- Atopic dermatitis (eczema)
- Atopic triad
- Psoriasis
- Contact dermatitis
- Diaper dermatitis
- Viral skin infections
- Herpes simplex
- Herpes zoster
- Bacterial skin infections
- Impetigo
- Cellulitis
- Parasitic skin infestations
- Scabies
- Skin cancer
- Basal cell carcinoma,
- Squamous cell carcinoma
- Melanoma
- Clinical cases
- Quiz